October 28, 2024
First modified-live M bovis vaccine for cattle launched by Zoetis
Zoetis, an animal health company, has launched the UK's and the world's first modified-live vaccine for Mycoplasma bovis in cattle, describing it as a "game-changer" for beef and dairy calves, Vet Times reported.
The new vaccine, named Protivity, is the result of decades of research and development. It is designed to stimulate the required cell-mediated immune response in calves, a process essential for optimising protection against M bovis.
According to Zoetis, Protivity induces a serological response that provides protection to calves by the age of six weeks. The vaccine is administered in two doses, subcutaneously in the neck, with 21 days between doses. The vaccination process can begin when calves are as young as one week old, and immunity is achieved 12 days after the basic vaccination scheme is completed.
Clinical studies cited by Zoetis demonstrate that Protivity reduces lung lesions by 74%, alleviates respiratory symptoms, and lowers fever. The studies also report an improvement in the average daily weight gain of calves by 100g and a reduction in the use of antibiotics.
Colin Penny, a veterinarian with Zoetis, highlighted the significance of Protivity in controlling M bovis. He said, "This is the first modified-live vaccine for M bovis, and despite the availability of various tools to manage respiratory disease, M bovis continues to present challenges."
He explained that M bovis lacks a cell wall, making it resistant to certain antibiotics. The bacterium's ability to form biofilms and express variable surface lipoproteins allows it to evade treatment and the host immune response.
Penny also recommended that Protivity be used in conjunction with other on-farm control measures to prime active immunity.
He emphasised the importance of a comprehensive bovine respiratory disease (BRD) control policy, which should include ensuring adequate intake of high-quality colostrum, maintaining proper nutrition, and upholding hygiene and air quality standards in calf sheds.
Zoetis believes that this new vaccine will offer an effective solution to farmers facing challenges with M bovis, improving animal health and reducing reliance on antibiotics.
- Vet Times